Group B streptococcus vaccines: one step further
نویسندگان
چکیده
منابع مشابه
Conjugate vaccines against group B Streptococcus types IV and VII.
Although rarely encountered, group B Streptococcus (GBS) types IV and VII have been isolated from infants and adults with invasive disease. This study was designed to determine the immunogenicity and efficacy in animals of conjugate vaccines prepared with GBS types IV and VII capsular polysaccharide (CPS). Despite the striking similarities in structure of these 2 carbohydrate antigens, high-tit...
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Linkage of bacterial capsular polysaccharides to proteins to create conjugate vaccines has had a dramatic impact on the health of children. Although unconjugated polysaccharides are poorly immunogenic in infants and some older children and adults, their covalent coupling with proteins stimulates T cell dependent antigenic recognition that profoundly enhances immunogenicity. In the decade since ...
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9.1 Introduction Streptococcus agalactiae (Group B Streptococcus, GBS) is a Gram-positive encapsulated bacterium possessing an array of virulence factors that render it capable of producing serious disease in susceptible hosts, in particular the human newborn (Maisey et al., 2008a). Notably, GBS is the leading cause of meningitis in the neonatal period (Brouwer et al., 2010; Thigpen et al., 201...
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Streptococcus agalactiae, commonly known as Group B Streptococcus (GBS), is an important neonatal pathogen known to cause sepsis, meningitis and pneumonia. Australian pregnant women undergo screening during pregnancy in an effort to eradicate GBS before delivery where transmission to the neonate can occur. Preventative treatment includes intrapartum antibiotic prophylaxis and results in widespr...
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ژورنال
عنوان ژورنال: The Lancet Infectious Diseases
سال: 2021
ISSN: 1473-3099
DOI: 10.1016/s1473-3099(20)30451-5